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Aktivin dan inhibin

Daripada Wikipedia, ensiklopedia bebas.
inhibin, alpha
Pengenal pasti
SimbolINHA
Gen NCBI3623
HGNC6065
OMIM147380
RefSeqNM_002191
UniProtP05111
Other data
LokusKromosom 2 q33-qter
inhibin, beta A
The Activin dimer, from 2ARV.pdb
Pengenal pasti
SimbolINHBA
Simbol alternatifactivin A
Gen NCBI3624
HGNC6066
OMIM147290
RefSeqNM_002192
UniProtP08476
Other data
LokusKromosom 7 p15-p13
inhibin, beta B
Pengenal pasti
SimbolINHBB
Simbol alternatifactivin B
Gen NCBI3625
HGNC6067
OMIM147390
RefSeqNM_002193
UniProtP09529
Other data
LokusKromosom 2 cen-q13
inhibin, beta C
Pengenal pasti
SimbolINHBC
Simbol alternatifactivin C
Gen NCBI3626
HGNC6068
OMIM601233
RefSeqNM_005538
UniProtP55103
Other data
LokusKromosom 12 q13
inhibin, beta E
Pengenal pasti
SimbolINHBE
Simbol alternatifactivin E
Gen NCBI83729
HGNC24029
OMIM612031
RefSeqNM_031479
UniProtP58166
Other data
LokusKromosom 12 q13.2

Aktivin dan inhibin adalah dua kompleks protein yang sangat berkaitan yang nyaris memiliki dampak bioologi yang berlawanan secara langsung. Diidentifikasikan pada 1986,[1][2] aktivin meningkatkan biosintesis dan sekresi FSH, dan berpartisipasi dalam regulasi siklus mesntrual. Beberapa fungsi lainnya yang ditimbulkan oleh aktivin, meliputi peran dalam proliferasi sel, diferensiasi, apoptosis,[3] metabolisme, homeostasis, respon kekebalahan, perbaikan luka,[4] dan fungsi endokrin. Sebagliknya, inhibin mengurangi sintesis FSH dan menghambat sekresi FSH.[5] Peberadaan inhibin dihipotesisasikan pada awal 1916. Namun, keberadaannya belum dinyatakan sampai dinyatakan ada oleh Neena Schwartz dan Cornelia Channing pada pertengahan 1970an, setelah kedua protein tersebut dikarakterisasikan secara molekuler pada sepuluh tahun kemudian.[6]

  1. ^ Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A, Woo W, Karr D, Spiess J (1986). "Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid". Nature. 321 (6072): 776–9. Bibcode:1986Natur.321..776V. doi:10.1038/321776a0. PMID 3012369. S2CID 4365045.
  2. ^ Ling N, Ying SY, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R (1986). "Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin". Nature. 321 (6072): 779–82. Bibcode:1986Natur.321..779L. doi:10.1038/321779a0. PMID 3086749. S2CID 38100413.
  3. ^ Chen YG, Wang Q, Lin SL, Chang CD, Chuang J, Chung J, Ying SY (May 2006). "Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis". Experimental Biology and Medicine. 231 (5): 534–44. doi:10.1177/153537020623100507. PMID 16636301. S2CID 39050907.
  4. ^ Sulyok S, Wankell M, Alzheimer C, Werner S (October 2004). "Activin: an important regulator of wound repair, fibrosis, and neuroprotection". Molecular and Cellular Endocrinology. 225 (1–2): 127–32. doi:10.1016/j.mce.2004.07.011. PMID 15451577. S2CID 6943949.
  5. ^ van Zonneveld P, Scheffer GJ, Broekmans FJ, Blankenstein MA, de Jong FH, Looman CW, Habbema JD, te Velde ER (March 2003). "Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women". Human Reproduction. 18 (3): 495–501. doi:10.1093/humrep/deg138. PMID 12615813.
  6. ^ Makanji Y, Zhu J, Mishra R, Holmquist C, Wong WP, Schwartz NB, Mayo KE, Woodruff TK (October 2014). "Inhibin at 90: from discovery to clinical application, a historical review". Endocrine Reviews. 35 (5): 747–94. doi:10.1210/er.2014-1003. PMC 4167436. PMID 25051334.

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